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Titel / Auteur(s)

Artikel in Reactie over Latex
A.H.P. Jansen, internist Allergoloog
Rubber is een elastisch materiaal dat verkregen wordt uit latex. NRL, natuurruberlatex, is het melksap uit de bast van de rubberboom Hevea brasiliensis. Het versgetapte latex ondergaat een aantal bewerkingsprocessen waarbij chemicaliën worden toegevoegd aan het latexconcentraat. Afhankelijk van het fabricageproces en van de soort en de hoeveelheid chemische toevoegingen, ontstaan rubberen eindproducten met een variérend latex-eiwit gehalte. --lees verder --

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Risks of allergic reactions to biotech proteins in foods: perception and reality /  S. B. Lehrer1, G. A. Bannon2 1Section of Clinical Immunology, Allergy and Rheumatology, Tulane University School of Medicine, New Orleans, LA; 2Product Characterization Center, The Monsanto Company, St Louis, MO, USA
In recent years, significant attention has been paid to the use of biotechnology to improve the quality and quantity of the food supply due in part to the projected growth in the world population, plus limited options available for increasing the amount of land under cultivation. Alterations in the food supply induced by classical breeding and selection methods typically involve the movement of large portions of genomic DNA between different plant varieties to obtain the desired trait. This is in contrast to techniques of genetic engineering which allows the selection and transfers specific genes from one species to another. The primary allergy risk to consumers from genetically modified crops may be placed into one of three categories. The first represents the highest risk to the allergic consumer is the transfer of known allergen or cross-reacting allergen into a food crop. The second category, representing an intermediate risk to the consumer, is the potential for replacing the endogenous allergenicity of a genetically-modified crop. The last category involves ...............

Allergy 2005: 60:
559–564

Bacterial and fungal components in house dust of farm children, Rudolf Steiner school children and reference children – the PARSIFAL Study  /
D. Schram1, G. Doekes1, M. Boeve1, J. Douwes1,2, J. Riedler3, E.
blagger3, E. von Mutius4, J. Budde4, G. Pershagen5, F. Nyberg5,6, J. Alm7,8, C. Braun-Fahrlnder9, M. Waser9 & B. Brunekreef1, on behalf of the PARSIFAL Study Group
Background: Growing up on a farm and an anthroposophic lifestyle are associated with a lower prevalence of allergic diseases in childhood. It has been suggested that the enhanced exposure to endotoxin is an important protective factor of farm environments. Little is known about exposure to other microbial components on farms and exposure in anthroposophic families.
Objective: To assess the levels and determinants of bacterial endotoxin, mould b(1,3)-glucans and fungal extracellular polysaccharides (EPS) in house dust of farm children, Steiner school children and reference children.
Methods: Mattress and living room dust was collected in the homes of 229 farm children, 122 Steiner children and 60 and 67 of their respective reference children in five European countries. Stable dust was collected as well. All samples were analysed in one central laboratory. Determinants were assessed by questionnaire.       
 

Allergy 2005: 60:
611–618

In search of a new paradigm: mechanisms of sensitization and elicitation of food allergy / L. K. Poulsen Laboratory of Medical Allergology, Allergy Clinic, National University Hospital, Copenhagen O, Denmark
In this review of research priorities, presented for the European Commission, food allergy is established as a disease with a considerable impact on modern society. Research paradigms have changed from establishing basic symptomatology and diagnostic methods over allergen characterization to a risk-identification approach looking at which patients are at risk of developing reactions to a certain dose of allergenic food. In order to solve some of the apparent paradoxes of regional, temporal, and species-related differences in sensitization and food allergic reactions, it is suggested to study the basic underlying mechanisms in the cross-field between immunology and gastroenterology. Research priorities should include the molecular basis of cross-reactivity, the digestion and maintenance of antigenicity, the genetics of food allergy, and the immune response to food antigens and effects on the gastrointestinal immune system by food matrices and the microbial gut-flora. Necessary methods with be spanning from molecular biology to large-scale clinical and epidemiological studies.
 

Copyright
 Blackwell Munksgaard 2005 ALLERGY DOI: 10.1111/j.1398-9995.2005.00821.x

Double-blind placebo-controlled challenges for peanut allergy / J. van Odijk1, S. Ahlstedt2,3, U. Bengtsson4, M. P. Borres2,5, L. Hulth
n1
Background: A firm diagnosis of double-blind placebo-controlled food challenge (DBPCFC) would facilitate the diagnosis in patients with uncertain history of reaction. Guidelines are lacking for an upper provoking dose and how to hide high concentrations of peanuts. Aim: To develop and evaluate a double-blind recipe with minimum 10% of peanut. To compare the recipe with published recipes regarding blindness, taste, texture and immunoglobulin (Ig)E antibody binding to peanut.
 

ALLERGY DOI: 10.1111/j.1398-9995.2005.00666.x

Standardization of food challenges in patients with immediate reactions to foods – position paper from the European Academy of Allergology and Clinical Immunology
C. Bindslev-Jensen1, B. K. Ballmer-Weber2, U. Bengtsson3, C. Blanco4, C. Ebner5, J. Hourihane6, A. C. Knulst7, D. A. Moneret-Vautrin8, K. Nekam9, B. Niggemann10, M. Osterballe1, C. Ortolani11, J. Ring12, C. Schnopp13, T. Werfel14
 

Allergy 2004: 59: 690–697

Outcomes of Allergy to Insect Stings in Children, with and without Venom Immunotherapy / David B.K. Golden,  M.D., Anne Kagey-Sobotka, Ph.D., Philip S. Norman, M.D., Robert G. Hamilton, Ph.D., and Lawrence M. Lichtenstein, M.D., Ph.D.
background Children are thought to “outgrow” the allergy to insect stings, but there are no reports documenting the natural history of this reaction. We studied the outcome of allergic reactions to insect stings in childhood 10 to 20 years afterward in patients who had not received venom immunotherapy and in those who had been treated.
methods Between 1978 and 1985, we diagnosed allergic reaction to insect stings in 1033 children, of whom 356 received venom immunotherapy. We conducted a survey of these patients by telephone and mail between January 1997 and January 2000, to determine the outcome of stings that occurred in the period from 1987 through 1999.
 

Negative venom skin test results and mastocytosis
To the Editor:
The recent rostrum article by the Insect Committee of the American Academy of Allergy, Asthma and Immunology in the September issue of the Journal presents important new recommendations for managing patients with negative venom skin test results despite histories of systemic reaction to an insect sting.1 In our view, the guidelines have to be supplemented by one very important issue. As the authors mention, a negative .......
 

J ALLERGY CLIN
IMMUNOL
doi:10.1016/j.jaci.2003.10.013

Why Are You Not Allergic?
by Kent T. HayGlass
Despite the fact that most environmental allergens are widely distributed, only a subset of << 1% to ~10% of the population usually develops clinically apparent allergic disease. To date, research has largely focused on identification of mechanisms that control induction or maintenance of such responses in individuals with clinical sensitivity. Immune responses in nonallergic individuals remain largely unstudied. Here, I address the controversy that attributes the continued failure of most of the population to develop clinical sensitivity despite ongoing allergen exposure to (i) immunologic unresponsiveness vs (ii) protective immune responses that actively inhibit induction and expression of Th2-biased immunity. Models that equate clinical tolerance with immunological tolerance are supported by recent studies on the role of immature dendritic cells (DC) in enforcing T cell unresponsiveness to non-threatening antigens. Models attributing clinical tolerance to protective immunity are supported by ubiquitous expression of distinctive allergen-dependent T cell cytokine and IgG4 responses in non-atopic individuals. Efforts to clearly identify the mechanisms that successfully maintain clinical tolerance in the majority of the population could provide novel approaches to decrease the prevalence and severity of allergic diseases.
 

RICHTLIJN 2003/89/EG VAN HET EUROPEES PARLEMENT EN DE RAAD van 10 november 2003 tot wijziging van Richtlijn 2000/13/EG met betrekking tot de de vermelding van de ingrediënten van levensmiddelen.
 

Clin Exp Allergy 2003; 33:1033–1040

Future therapeutic options in food allergy / P.A. Eigemann, Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland
Up to 5% of young children and 2% of adults suffer from food allergy. Among them many have immunoglobulin E (IgE)-mediated food allergy, a condition with potentially fatal allergic reactions. Several studies have addressed possible definite treatment options for food allergy. Immunotherapy, by the oral route or by systemic injections shows promising preliminary results, but current interpretation of these therapeutic options are mostly handicapped by studies with insufficient scientific support, or by severe side-effects. Currently, no studies can support pharmacotherapy. Finally, most promising results were recently published with anti-IgE antibodies in a human trial, or various approaches in a mouse model of food allergy (chinese herbal medicine, specific modulation of the T cell response). Rapidly evolving findings might provide hope for a cure of food allergy in the near future.
 

Allergy 2003:
58: 1217–1223

The Evaluation and Management of Food Allergy in Atopic Dermatitis / HUGH A. SAMPSON, MD
Atopic dermatitis (AD) is a form of eczema that generally begins in early infancy and is characterized by extreme pruritus, chronically relapsing course, and distinctive morphology and distribution. AD is typically the first clinical manifestation of a child prone to develop atopic disease, with 50% of all AD developing in the first year of life and 80% by 5 years of age. Approximately 80% of children with AD develop asthma or allergic rhinitis; many lose their AD with the onset of respiratory allergy.
 

Clinics in
Dermatology
Y 2003;21:183–192

aug 2003

April 2003

Anaphylaxis Matthew I. Fogg, MD, Nicholas A. Pawlowski, MD
As the end of the winter season infectious diseases approaches, the early blooms remind us that allergy season is also beginning. Food allergy is with us the entire year, as children are exposed daily to many food  antigens that may trigger a reaction. This helpful article reviews the problem from basic science to management.
I found it helpful to see the list of possible offending foods and the written management plan that the authors provide. They emphasize that the avoidance of the food is the only successful long-term management for food allergy although new treatments for peanut allergy seem quite promising. Early use of epinephrine may save a life, so we are reminded of the value of home treatment with epinephrine. This review of food allergy diagnosis and management should help us take better care of our patients.
 

Pediatric Case
Reviews
Volume 3  
Number 2
 

Allergies to Cross-Reactive Plant Proteins Latex-Fruit Syndrome Is Comparable with Pollen-Food Allergy Syndrome / Takeshi Yagami
Abstract
Both latex-fruit syndrome and oral allergy syndrome concomitant with pollinosis (pollen-food allergy syndrome) are considered to be caused by cross-reactivity between sensitizers and symptom elicitors. The crossreactive food allergens relevant to these syndromes are mostly sensitive to heat and digestive enzymes. Such a vulnerable antigen cannot sensitize people perorally but provokes allergic reactions in already sensitized patients based on its cross-reactivity to the corresponding sensitizer. These types of food allergens are often called incomplete food allergens or nonsensitizing elicitors. Their features contrast with those of complete food allergens that have the capacity for peroral sensitization as well as symptom elicitation. Although highly antigenic and cross-reactive, carbohydrate epitopes do not generally elicit allergic reactions and often disturb in vitro IgE tests. Recent research .......
 

'May Contain’ Labelling – The Consumer’s Perspective / The Food Standards Agency Aviation House 125 Kingsway London WC2B 6NH Project Officer: Dionne Davey Chemical Safety and Toxicology Division
Engelstalig rapport over hoe de allergische consument de waarschuwende etikettering ervaart.
 

Published by the Food Standards Agency
May 2002 FSA/0582/0502

Breast feeding does not protect against atopy / Susan Mayor London

BMJ VOLUME 325 28 SEPTEMBER 2002

Food-Allergic Reactions in Schools and Preschools  / Anna Nowak-Wegrzyn, MD; Robert A. Wood, MD;
Mary Kay Conover-Walker, MSN, RN, CRNP;
Kort Engels artikel over een telefonisch onderzoek onder de ouders van 132 schoolgaande kinderen die voedselallergie hebben. 58% rapporteerde allergische reacties te hebben gehad in de afgelopen twee jaar. en 18% had dit meer dan 1 maal.
 

Position paper A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force
 

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www.RestaurantEnAllergie.nl
 

Het Archief!
Hier vindt u oudere en reeds eerder geplaatse informatie over onderzoeken die gepubliceerd zijn in Professionele peer review bladen over dit vakgebied.

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De Epinephrine Mate, dé houder voor de epinefrine-auto-injector, speciaal voor de  EpiPen®

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Het Actieplan, Het communicatie-hulpmiddel bij de beheersing van uw allergie.

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